Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

447
Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
447
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

963
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
963
Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

10.1K
Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
10.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Correlation Between the Presence of <i>BRAF<sup>V600E</sup></i> and <i>TERT</i> Promoter Mutation and the Response to Treatment with Iodine 131 in Differentiated Thyroid Cancer Patients.

Genes·2026
Same author

One-Year Comparative Outcomes of Conventional Versus Accelerated Corneal Cross-Linking in Progressive Keratoconus.

Medicina (Kaunas, Lithuania)·2026
Same author

Systemic cardiac migration of perfluorocarbon liquid following unsuccessful endoresection of choroidal melanoma: a case report.

Future cardiology·2026
Same author

Clinicopathological Characteristics and BAP1 Expression in an Enucleation-Based Uveal Melanoma Cohort: A Single-Center Croatian Experience with Long-Term Follow-Up.

Cancers·2026
Same author

Non-Infectious Anterior Uveitis Is Associated with Functional Retinal Changes Demonstrable by Multifocal Electroretinography.

Journal of clinical medicine·2026
Same author

Editorial: Prevention and treatment advancements in diabetic retinopathy.

Frontiers in endocrinology·2026

Related Experiment Video

Updated: Jan 18, 2026

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models
06:10

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Published on: December 8, 2023

2.4K

RhoKinase (ROCK) Inhibition as a Therapeutic Strategy for Pseudophakic Bullous Keratopathy: A Comprehensive Review.

Anđela Jukić1, Josip Pavan1, Biljana Đapic Ivančić2

  • 1Department of Ophthalmology, University Hospital Dubrava, 10000 Zagreb, Croatia.

Journal of Clinical Medicine
|September 13, 2025
PubMed
Summary

Rho-kinase (ROCK) inhibitors show promise for treating pseudophakic bullous keratopathy (PBK), a complication of cataract surgery. These drugs may improve corneal health and reduce the need for transplantation.

Keywords:
Rho-kinase inhibitorscorneal endotheliumcorneal oedemanetarsudilpseudophakic bullous keratopathyripasudil

More Related Videos

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.3K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.8K

Related Experiment Videos

Last Updated: Jan 18, 2026

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models
06:10

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Published on: December 8, 2023

2.4K
Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.3K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.8K

Area of Science:

  • Ophthalmology
  • Corneal Disease
  • Pharmacology

Background:

  • Pseudophakic bullous keratopathy (PBK) is a serious complication after cataract surgery, causing vision loss due to corneal swelling and blisters.
  • Current treatments like corneal transplantation face issues such as donor scarcity and graft failure.

Purpose of the Study:

  • To evaluate Rho-kinase (ROCK) inhibitors as a novel pharmacological treatment for PBK.
  • To assess the potential of ROCK inhibitors to improve corneal function and reduce the need for transplantation.

Main Methods:

  • A systematic literature search was performed across PubMed, Scopus, and Web of Science.
  • Included peer-reviewed, English-language articles detailing preclinical and clinical studies on ROCK inhibitors for PBK.

Main Results:

  • ROCK inhibitors promote corneal endothelial cell growth, migration, and survival while reducing cell death.
  • Studies indicate ROCK inhibitors improve corneal clarity, reduce edema, and enhance visual acuity in PBK patients.
  • These agents may delay or eliminate the need for corneal transplantation.

Conclusions:

  • ROCK inhibitors offer a promising new therapeutic avenue for managing PBK.
  • This approach could decrease reliance on donor corneal grafts.
  • Further research is required to establish long-term safety and optimal usage protocols.