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The Nasser-Gavvala-Shirodkar-Botchu Classification: A Classification System for Loosening of Endoprosthetic
Ahmed Abdul Hadi Harb Nasser1, Sai Niharika Gavvala2, Kapil Shirodkar3
1The Royal Orthopaedic Hospital, Birmingham B31 2AP, UK.
Journal of Clinical Medicine
|September 13, 2025
Summary
A new classification system for femoral endoprosthesis replacement (EPR) loosening was developed. Grade 3 loosening around the EPR shaft was the most common failure pattern observed in this study.
Area of Science:
- Orthopedic surgery
- Biomedical engineering
- Radiology
Background:
- Femoral endoprosthesis replacement (EPR) is increasingly used in limb reconstruction.
- Loosening is the primary cause of EPR failure.
- A standardized classification for EPR loosening is lacking.
Purpose of the Study:
- To introduce a novel, reproducible classification system for femoral endoprosthesis replacement (EPR) loosening.
- To categorize loosening based on anatomical location relative to the prosthesis.
Main Methods:
- Retrospective review of radiographs and CT scans from 28 adult patients undergoing revision EPR for loosening.
- Development of a 6-grade classification system based on loosening location and associated complications.
- Analysis of patient demographics and time to loosening diagnosis.
Main Results:
- Grade 3 loosening (around the prosthesis shaft) was the most frequent pattern, observed in 57.1% of cases.
- The average time from initial surgery to diagnosis of loosening was 10.1 years.
- The majority of patients were male (61%) with a mean age of 50.6 years.
Conclusions:
- The proposed classification system offers a simple and reproducible method for describing EPR loosening.
- This system has the potential to guide revision surgical strategies and improve future EPR designs.
- Standardized evaluation of loosening can aid in developing national guidelines for managing this complication.
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