Related Experiment Video
Updated: Jan 18, 2026
06:45
In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System
Published on: July 2, 2020
4.7K
An Intracellular Magnetic Micromotor Drives Spatiotemporal Mechano-Immunotherapy
Rui Gao1,2,3, Chang Xu1,2,3, Chen Liu4
1Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China.
Advanced Materials (Deerfield Beach, Fla.)
|September 13, 2025
Summary
This study introduces intelligent intracellular magnetic torque (IIMT) to control cancer-immunity cycles. This mechano-immunotherapy approach enhances immunotherapy effectiveness against solid tumors.
Area of Science:
- Biomedical Engineering
- Immunology
- Nanotechnology
Background:
- Effective cancer immunotherapy is hindered by challenges in coordinating the cancer-immunity cycle.
- Solid tumors present unique obstacles for conventional immunotherapies.
Purpose of the Study:
- To design an intelligent intracellular magnetic torque (IIMT) paradigm for spatiotemporal orchestration of tumor cells and antigen-presenting cells (APCs).
- To integrate IIMT with rotating magnetic fields to enhance immunotherapy efficacy.
- To explore the potential of mechano-immunotherapy through intracellular mechanics.
Main Methods:
- Engineered rod-shaped magnetic micromotors to generate tunable torques within lysosomes.
- Applied high-intensity torques to induce tumor immunogenic cell death and antigen release.
- Applied low-intensity torques to trigger lysosomal antigen leakage for APC cross-presentation and activate NLRP3 inflammasome.
Main Results:
- Demonstrated spatiotemporal control over cellular functions using IIMT.
- Showcased sequential IIMT's ability to boost antitumor immunity.
- Achieved synergistic enhancement of anti-programmed cell death protein 1 antibody (anti-PD-1) therapy.
Conclusions:
- Developed a novel magnetic torque-based strategy for driving the cancer-immunity cycle.
- Established IIMT as a promising approach for mechano-immunotherapy.
- Opened new avenues for exploring mechanobiology and immunity via intracellular mechanics.
