Multifunctional Hydrogel Dressing Based on Glycosylated Collagen-Curcumin Nanoparticles Effectively Accelerates Wound...

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Wound Healing

Background:

• Multifunctional hydrogels are crucial for advanced wound healing applications.
• Developing dressings with combined therapeutic properties is a key research area.

Purpose of the Study:

• To develop a novel hydrogel dressing with antioxidant, antibacterial, anti-inflammatory, and wound healing capabilities.
• To utilize xylose-glycated Chinese giant salamander collagen (CGSPXy) and curcumin (Cur) for enhanced hydrogel performance.

Main Methods:

• Forming a hydrogel framework by mixing CGSP/CGSPXy-Cur nanoparticles with sodium alginate (SA) via hydrogen bonding.
• Creating an ion-crosslinked semi-interpenetrating double-network hydrogel using Ca²⁺ and chitosan (CS).

Main Results:

• The CGSPXy-Cur hydrogel exhibited improved thermal stability, rheological properties, adhesion, and tensile strength.
• In vitro studies showed sustained curcumin release, good hemocompatibility, clotting ability, antioxidant, and antibacterial activity.
• The hydrogel effectively promoted wound healing by enhancing collagen deposition, angiogenesis, and myofibroblast generation while reducing pro-inflammatory factors.

Conclusions:

• The developed collagen-based hydrogel dressing shows significant potential for wound care.
• The synergistic effects of CGSPXy and Cur contribute to enhanced wound healing properties.