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NIBAN2 Stimulates Glioma Growth by Regulating the JAK2/STAT3/c-Myc Pathway

Zhi-Ming Chen1,2, Lei Mou3, Yi-Heng Pan3

  • 1Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.

Cancer Medicine
|September 13, 2025
PubMed
Abstract

Insights

Niban-like protein 2 (NIBAN2) promotes glioma aggressiveness and tumor growth by activating the JAK2/STAT3 pathway. This finding identifies NIBAN2 as a potential therapeutic target for improving glioma prognosis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Neuroscience

Background:

  • Niban-like protein 2 (NIBAN2) is implicated in neurological diseases, but its role in glioma is unknown.
  • Glioma is a primary brain tumor with significant impact on patient outcomes.

Purpose of the Study:

  • To investigate the role of NIBAN2 in glioma development and progression.
  • To explore NIBAN2 as a potential therapeutic target for glioma.

Main Methods:

  • Quantitative reverse transcription-polymerase chain reaction, western blotting, and immunohistochemistry were used to assess NIBAN2 expression in glioma tissues.
  • Functional assays and animal models were employed to evaluate NIBAN2's effects on glioma cell aggressiveness, tumor growth, apoptosis, and cell cycle.
  • The study examined the involvement of the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway.

Main Results:

  • NIBAN2 was significantly upregulated in gliomas, with expression levels correlating with tumor grade and clinical outcomes.
  • NIBAN2 enhanced glioma cell aggressiveness by activating the JAK2/STAT3 signaling pathway.
  • NIBAN2 promoted tumor growth by inhibiting apoptosis and accelerating the cell cycle.

Conclusions:

  • NIBAN2 plays a critical role in glioma aggression and is associated with poor prognosis.
  • NIBAN2 represents a promising therapeutic target for the treatment of gliomas.
Keywords:
JAK2/STAT3/MYCNIBAN2gliomasproliferation

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