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Direct Vocal Fold Testosterone Injection for Treatment of Sulcus Vocalis: A Case Report
Rohith S Voora1, Michelle K Tenggara2, Benjamin Schiedermayer1
1Division of Otolaryngology-Head & Neck Surgery, University of California, San Diego, San Diego, California, USA.
The Laryngoscope
|September 13, 2025
Summary
Targeted vocal fold testosterone injections offer a novel, minimally invasive treatment for sulcus vocalis. This approach improved vocal function and patient outcomes, suggesting a new therapeutic avenue for voice disorders.
Area of Science:
- Otolaryngology
- Endocrinology
- Regenerative Medicine
Background:
- Sulcus vocalis causes persistent voice difficulties unresponsive to conventional treatments.
- Minimally invasive therapeutic options for vocal fold sulcus are limited.
- Androgen receptor signaling's role in vocal fold tissue remodeling is not fully understood.

