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![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Visible-Light-Mediated Three-Component Minisci-Type Reaction of 4-Cyanopyridines
Enfan Pu1, Yanren Zhu1, Shaoxiong Yang1
1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, School of Pharmacy, Yunnan University, Kunming 650500, P. R. China.
Abstract:
Herein we report a metal-free photocatalytic three-component Minisci-type reaction that simultaneously installs both amide and cyanopyridine functionalities into alkenes in a single step. This strategy enables rare C2-selective functionalization of 4-cyanopyridines, exhibiting regioselectivity complementary to ipso substitution at C4. This protocol proceeds under mild conditions and retains the cyano group with broad substrate scope and excellent functional group compatibility, while the absence of cyanide release and metal catalysts aligns with contemporary green chemistry principles.
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