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Updated: Jan 17, 2026

In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids
Published on: November 18, 2022
Synergistic effect of self-assembled cinnamon essential oil-proanthocyanidin colloidal dispersion on in vitro starch
Zhihao Duan1, Mianhong Chen2, Yunxia He2
1Key Laboratory of Tropical Crop Products Processing of Ministry of Agriculture and Rural Affairs, Agricultural Products Processing Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang, Guangdong 524001, China; College of Food Science and Technology, Yunnan Agricultural University, Kunming, Yunan 650000, China.
Abstract:
Cinnamon essential oil (CEO) and proanthocyanidin (PC), natural food-grade materials, show potential for managing hyperglycemia and hyperlipidemia. In this study, a surfactant-free ultrasonic method was used to prepare the self-assembled CEO-PC colloidal dispersion (CEO-PC-CD), with the optimal concentrations of CEO and PC determined to be 20.0 and 10.0 mg/mL, respectively. The CEO and PC self-assembled into spherical nanoparticles, which were predominantly stabilized in the aqueous phase by π-π stacking and hydrogen bonding interactions. The in vitro antioxidant capacity of CEO-PC-CD, along with its inhibitory effects on α-amylase, α-glucosidase, and pancrelipase, was found to be more potent than those of the individual components. During the simulated in vitro digestion process, CEO-PC-CD effectively inhibited glucose, reducing sugar, and free fatty acid generation, with maximum inhibition rates of 54.46 %, 88.13 %, and 54.25 %, respectively. This study offers a novel carrier-free strategy for developing functional foods with enhanced glycemic control potential.
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