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Multicolor Fluorescence Detection for Droplet Microfluidics Using Optical Fibers
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Bimodal optical fiber biosensor with high anti-interference based on two-photon polymerization 3D nanofabrication
Pengqi Gong1, Xuegang Li2, Xue Zhou3
1State Key Laboratory of Synthetical Automation for Process Industries, Northeastern University, Shenyang, Liaoning, 110819, China; College of Information Science and Engineering, Northeastern University, Shenyang, Liaoning, 110819, China.
Biosensors & Bioelectronics
|September 14, 2025
Summary
This study presents a novel dual-mode optical fiber sensor for simultaneous bulk and surface refractive index detection. This advanced sensor enables precise biological detection in complex environments with high accuracy.
Area of Science:
- Optoelectronics
- Nanotechnology
- Biomedical Sensing
Background:
- Accurate detection of biomolecules in complex biological samples is challenging.
- Existing sensors often struggle to differentiate between bulk and surface refractive index changes.
- Need for sensitive and specific biosensors for early disease diagnosis and monitoring.
Purpose of the Study:
- Develop a micro/nano dual-mode optical fiber sensor for simultaneous bulk refractive index (BRI) and surface refractive index (SRI) detection.
- Utilize two-photon polymerization 3D processing for micro/nano fabrication.
- Enable sensitive and specific detection of biomolecules in complex biological matrices.
Main Methods:
- Fabrication of a dual-mode optical fiber sensor using two-photon polymerization 3D processing.
- Integration of surface plasmon resonance (SPR) for SRI detection and Fabry-Perot interference (FPI) for BRI detection.
- Development of a microfluidic chip for liquid-phase analysis with minimal sample volume (5 μL).
Main Results:
- Simultaneous detection of BRI and SRI with detection limits of 4 × 10⁻⁴ RIU and 1.2 nM, respectively.
- Accurate DNA concentration analysis (error < 3.7%) in simulated biological samples (fetal bovine serum).
- Demonstrated sensor consistency and specificity in diverse environmental conditions.
Conclusions:
- The developed dual-mode optical fiber sensor effectively discriminates BRI and SRI changes for robust biological detection.
- The sensor's ability to handle complex environments and provide accurate quantification is crucial for real-world applications.
- This technology holds significant potential for advancing biosensing platforms in diagnostics and research.
