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Related Concept Videos

Bone Disorders01:29

Bone Disorders

5.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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What is the Skeletal System?01:02

What is the Skeletal System?

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Overview
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

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Osteoporosis.

Carrie Ye1, Peter Ebeling2, Gregory Kline3

  • 1Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; Northern Alberta Osteoporosis Program, Alberta Health Service, Edmonton, AB, Canada.

Lancet (London, England)
|September 14, 2025
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Summary
This summary is machine-generated.

Osteoporotic fractures are a major health concern in aging populations. This seminar provides updated clinical guidance on osteoporosis screening, risk assessment, and effective treatments, including safe medication management.

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Area of Science:

  • Gerontology
  • Orthopedics
  • Pharmacology

Background:

  • Osteoporotic fractures represent a significant health burden in aging individuals.
  • Despite available therapies, osteoporosis treatments remain underutilized.
  • An updated clinical approach is needed to address this challenge.

Purpose of the Study:

  • To present an updated, evidence-based approach to osteoporosis consultation for clinicians.
  • To provide pragmatic guidance on managing osteoporosis and preventing fractures.
  • To consolidate current evidence and expert opinion for practical clinical application.

Main Methods:

  • Review of published evidence on osteoporosis management.
  • Collaborative expert opinion synthesis.
  • Focus on updated screening, risk assessment, and therapeutic interventions.

Main Results:

  • Discussion of new evidence on screening and fracture-risk assessment.
  • Guidance on intervention decisions, including nutritional and pharmacological therapies.
  • Practical strategies for treating complex patient populations and managing treatment discontinuation.

Conclusions:

  • An updated, evidence-based approach can optimize osteoporosis management.
  • Effective screening, risk assessment, and tailored therapies are crucial for fracture prevention.
  • Safe management strategies, including medication discontinuation, are essential for patient safety.