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Anti-inflammatory iridoid and phenylethanoid glycosides from Xylanche himalaica
Wei Nie1, Yan Guo1, Zhi-Da Zi1
1Yunnan Institute of Materia Medica, Kunming 650111, PR China; Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation, Kunming 650111, PR China.
Abstract:
Two previously undescribed iridoid glycosides, designated as xylancoside A (1) and xylancoside B (2), together with two phenylethanoid glycosides, namely xylanchoside A (3) and xylanchoside B (4), were isolated from Xylanche himalaica and thoroughly characterized. The structures and absolute configurations of these compounds were unambiguously determined by means of NMR spectroscopic data analysis, acid hydrolysis, and quantum chemical calculations. Compounds 1-4 were found to exhibit anti - inflammatory activities with differential potencies, as manifested by their capacity to inhibit the secretion of cytokines IL-6 and TNF-α in lipopolysaccharide (LPS)-induced RAW264.7 macrophages.
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