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Correlation between quantitative OCT metrics and contrast sensitivity function in retinal artery occlusion.

Chong Chen1,2,3, Rajiv M Sastry1, Leiyu Wang1

  • 1Harvard Retinal Imaging Lab, Harvard Medical School, Boston, Massachusetts, USA.

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|September 14, 2025
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Summary

Quantitative contrast sensitivity function (qCSF) correlates with optical coherence tomography (OCT) biomarkers in retinal artery occlusion (RAO). OCT measures like inner nuclear layer thickness and ischemia proximity are linked to reduced contrast sensitivity, not just visual acuity.

Keywords:
Optical coherence tomographyQuantitative contrast sensitivity functionRetinal artery occlusionStructural-functional correlation

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Diagnostic Imaging

Background:

  • Retinal artery occlusion (RAO) can impair vision.
  • Visual acuity (VA) may not fully capture functional deficits in RAO.
  • Optical coherence tomography (OCT) provides structural insights into retinal damage.

Purpose of the Study:

  • To explore the relationship between OCT-derived biomarkers and contrast sensitivity (CS) using the quantitative contrast sensitivity function (qCSF) in RAO patients.
  • To evaluate qCSF as a functional measure in RAO, particularly in relation to OCT findings.

Main Methods:

  • A cross-sectional study involving RAO patients and age-matched controls.
  • Participants underwent visual acuity (VA), qCSF testing, and spectral-domain OCT.
  • OCT quantified retinal layer thickness, ischemia size, and foveal proximity; linear regression was used.

Main Results:

  • RAO eyes showed significantly reduced qCSF metrics compared to controls.
  • Inner nuclear layer (INL) thickness correlated with VA and all qCSF parameters.
  • Ischemia size and foveal proximity were associated with reduced contrast sensitivity at various spatial frequencies, but not VA.

Conclusions:

  • qCSF demonstrates strong correlations with INL thickness and ischemia metrics in RAO.
  • qCSF serves as a valuable functional measure complementary to VA in RAO.
  • qCSF is a meaningful clinical endpoint for evaluating RAO, especially in foveal-sparing cases.