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PET-CT in the Management of Metastatic Neuroendocrine Tumors by Interventional Oncology
Arsalan Seyedi1, Fereshteh Yazdanpanah2, Stephen J Hunt3
1Department of Endocrinology, Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Imam Khomeini Hospital, School of Medicine, Tehran, Iran; Department of Radiology Penn Image-Guided Interventions Laboratory, University of Pennsylvania, PA, USA.
Abstract:
This article highlights the role of PET-computed tomography (CT) imaging in diagnosing and managing metastatic neuroendocrine tumors (mNETs). PET-CT, particularly with Gallium-68-DOTATATE, allows earlier and more precise detection of lesions compared to conventional imaging. It identifies somatostatin receptor-positive tumors, aiding in staging, interventional procedures, and guiding peptide receptor radionuclide therapy. The complementary use of fluorodeoxyglucose-PET for predicting tumor biology and managing aggressive, poorly differentiated tumors, helps provide a comprehensive framework for personalized mNETs management. Finally, PET-CT's role in patient diagnosis, staging, surveillance, and management by the interventional oncologist is outlined in detail.
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