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Updated: Apr 28, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
Apremilast for refractory major recurrent aphthous stomatitis involving the posterior pharyngeal wall: a case report
Tinglan Yang1, Jiankang Yang2, Qing Liu1
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Medicine, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China.
Abstract:
This case report describes a 37-year-old woman with refractory major recurrent aphthous stomatitis (RAS) who presented with a persistent 10-month posterior pharyngeal ulcer that was unresponsive to conventional treatments. Laboratory tests revealed elevated IL-6 and C-reactive protein. After excluding other related diseases, treatment with apremilast led to complete ulcer healing within 3 months, with normalization of IL-6 and no new ulcers during 8 months of follow-up. This case suggests the potential therapeutic benefits of apremilast in severe pharyngeal RAS refractory to conventional therapies.
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