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The Emerging Landscape of LINC01123 in Cancer: Roles, Mechanisms, and Clinical Significance
Jingjie Yang1,2, Fan Peng1,2, Haodong He1,2
1Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, China.
Current Drug Targets
|September 15, 2025
Summary
Long intergenic non-coding RNA 01123 (LINC01123) is an oncogene upregulated in many cancers. This review highlights LINC01123
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- Long intergenic non-coding RNA 01123 (LINC01123) is a lncRNA on human chromosome 2q13.
- LINC01123 is upregulated in various cancers, acting as an oncogene.
- Its expression correlates with cancer risk and poor prognosis.
Purpose of the Study:
- To analyze the expression patterns of LINC01123 in cancers.
- To investigate the oncogenic mechanisms of LINC01123.
- To evaluate the clinical significance of LINC01123 in cancer prognosis.
Main Methods:
- Systematic literature search in PubMed, Web of Science, and Google Scholar.
- Search term: "LINC01123".
- Review of retrieved studies on LINC01123 expression, mechanisms, and clinical significance.
Main Results:
- LINC01123 is activated by transcription factors like c-Myc, ZEB1, and FOXC1.
- It promotes cancer progression, metastasis, and drug resistance via miRNA sponging, pathway activation, or protein interactions.
- Upregulation of LINC01123 correlates with adverse clinicopathological features and poor prognosis.
Conclusions:
- LINC01123 has a multifaceted role in cancer biology.
- It shows potential as a prognostic biomarker and therapeutic target due to its gene regulation capabilities.
- Further research is needed to fully understand its mechanisms and clinical applications.
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