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Rheumatoid Factor and Anti-CCP Titers in COVID-19
Mudathir Abdelshafea Abdelkareem Abakar1, Mohamed Ibrahim Awadab1, Zohair Khalid Ibrahim Elaraki1
1Department of Microbiology and Clinical Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum North, Sudan.
Infectious Disorders Drug Targets
|September 15, 2025
Summary
COVID-19 patients showed significantly increased rheumatoid factor levels compared to healthy individuals. This suggests that Coronavirus Disease 2019 may contribute to the development of autoantibodies, impacting disease pathogenesis.
Area of Science:
- Immunology
- Virology
- Rheumatology
Background:
- The precise mechanisms of Coronavirus Disease 2019 (COVID-19) are not fully understood.
- Investigating autoantibodies in COVID-19 patients is crucial for understanding disease pathogenesis.
Purpose of the Study:
- To investigate the presence of autoantibodies in COVID-19 patients.
- To determine the association between COVID-19 and autoantibodies, specifically rheumatoid factor and anti-CCP antibodies.
Main Methods:
- A cross-sectional, hospital-based study was conducted with 90 participants.
- Participants were divided into three groups: COVID-19, rheumatoid arthritis, and a healthy control group.
- Serum concentrations of rheumatoid factor and anti-CCP antibodies were measured.
Main Results:
- Significant elevations in rheumatoid factor and anti-CCP antibodies were observed in the rheumatoid arthritis group.
- COVID-19 patients exhibited a significant increase in rheumatoid factor compared to the control group.
- No significant increase in anti-CCP antibodies was found in COVID-19 patients compared to controls.
Conclusions:
- COVID-19 is associated with a significant increase in rheumatoid factor levels.
- These findings suggest that COVID-19 may promote the development of autoantibodies.
- Rheumatoid factor may play a critical role in the pathogenesis of COVID-19 infection.
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