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Updated: Jan 17, 2026
A Protocol for the Administration of Real-Time fMRI Neurofeedback Training
Published on: August 24, 2017
Systematic review and meta-analysis of the relationships between real-time neurofeedback training parameters and
Eldrick V Galang1, Miguel A Velásquez2, Dehan Elcin2
1Department of Cognitive Science, School of Social Sciences, University of California, San Diego, San Diego, CA, United States.
Introduction:
Real-time neurofeedback is an emerging method for regional modulation of neural activity with physiological and behavioral effects that persist beyond the duration of feedback sessions. However, many individuals fail to achieve successful modulation, a challenge known as the "neurofeedback inefficacy problem." This study examined how methodological parameters of neurofeedback training influence the acquisition and retention of neural modulation in healthy adults.
Methods:
A systematic search identified eligible studies, resulting in 55 participant groups included in the meta-analysis. Standardized mean differences (Hedges' g) were calculated for changes in neural activity from first to last session and from pre- to post-training. Subgroup analyses and meta-regression were conducted to assess the impact of discrete and continuous moderators.
Results:
This meta-analysis identified four parameters associated with significant neural modulation in the desired direction: the neurofeedback imaging device used, complexity of the feedback stimulus, presence of a pre-training rehearsal trial, and EEG target oscillations.
Discussion:
This meta-analysis highlights key methodological factors that shape neurofeedback efficacy in non-clinical populations. Findings may serve to better understand how methodological variables used in neurofeedback influence the acquisition and retention of neural modulation.
Systematic Review Registration:
https://www.crd.york.ac.uk/PROSPERO/view/CRD42022357160, identifier: CRD42022357160.
