Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lung ultrasound findings in neonatal viral pneumonia: case series and literature review.

European journal of pediatrics·2026
Same author

Regarding: Global kidney health: Are we failing the silent pandemic?

Journal of internal medicine·2026
Same author

Surfactant-Budesonide Combination to Prevent Death or Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis.

Neonatology·2026
Same author

Task-free functional connectivity changes before and after hyper- and hypoglycemia in very preterm neonates.

Neurophotonics·2026
Same author

Neurobehavioral outcomes at 12 months in very preterm infants monitored with continuous glucose monitoring at birth compared with full-term infants.

Scientific reports·2026
Same author

Lung aeration and gas exchange in preterm infants developing moderate-to-severe bronchopulmonary dysplasia: a multicentre prospective study from the PATH-BPD cohort.

The Lancet regional health. Europe·2026

Related Experiment Video

Updated: Jan 17, 2026

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies
07:12

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Published on: November 19, 2020

2.5K

Investigating brain haemodynamics during hypoglycaemia in very preterm neonates using diffuse optical tomography.

Guy A Perkins1, Silvia Guiducci2, Giulia Res2

  • 1Department of Developmental Psychology and Socialization, University of Padova, Via Venezia, 8, 35131, Padova, Italy.

Medrxiv : the Preprint Server for Health Sciences
|September 15, 2025
PubMed
Summary

Very preterm newborns can experience blood sugar fluctuations. This study reveals a connection between glucose levels and brain blood flow in these infants, using continuous glucose monitoring and diffuse optical tomography.

Keywords:
hypoglycaemiapreterm and diffuse optical tomography

More Related Videos

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
11:39

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

21.0K
Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

8.5K

Related Experiment Videos

Last Updated: Jan 17, 2026

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies
07:12

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Published on: November 19, 2020

2.5K
Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
11:39

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Published on: March 14, 2013

21.0K
Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

8.5K

Area of Science:

  • Neonatal physiology
  • Neuroscience
  • Medical technology

Background:

  • Very preterm neonates are susceptible to hyperglycemia and hypoglycemia post-birth.
  • Limited understanding exists regarding the brain's hemodynamic response to glycemic variations in this population.

Purpose of the Study:

  • To investigate the relationship between glycemic changes and local brain hemodynamic responses in very preterm neonates.
  • To explore the impact of hypoglycemia on cerebral blood volume in early neonatal life.

Main Methods:

  • Utilized continuous glucose monitoring (CGM) and diffuse optical tomography (DOT) for simultaneous data acquisition.
  • Monitored sixty very preterm neonates over several days post-birth.
  • Analyzed DOT data during hypoglycemic events in 17 neonates, correlating sensor glucose concentration (SGC) with blood volume changes.

Main Results:

  • Found correlations between changes in blood volume and SGC during hypoglycemic events.
  • Observed spatial consistencies in hemodynamic responses across different time windows of hypoglycemia.
  • Indicated a coupling between SGC and brain hemodynamics in very preterm newborns.

Conclusions:

  • Glycemic fluctuations, specifically hypoglycemia, are associated with altered brain hemodynamics in very preterm neonates.
  • This study provides initial evidence of a link between glucose regulation and cerebral blood flow in this vulnerable population.
  • Highlights the potential of combined CGM and DOT for monitoring neonatal brain health.