Related Experiment Video

Updated: Jan 17, 2026

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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Published on: November 14, 2017

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Phenotypic and Genetic Associations Between Cardiovascular Disease Subtypes and Alzheimer's Disease

Aili Toyli1, Chen Zhao2, Kuan-Jui Su3

  • 1Department of Mathematical Sciences, Michigan Technological University, Houghton, MI, USA 49931.

Medrxiv : the Preprint Server for Health Sciences
|September 15, 2025
PubMed

Insights

Cardiovascular diseases (CVD) are linked to Alzheimer's disease (AD). Hypotension, hypertension, and cerebral infarction showed the strongest associations with AD risk, highlighting vascular health's role in cognitive decline.

Area of Science:

  • Neuroscience
  • Cardiology
  • Genetics

Background:

  • Cardiovascular disease (CVD) and Alzheimer's disease (AD) are significant public health issues with shared risk factors and pathways.
  • The precise relationship between AD and specific CVD subtypes requires further investigation.

Purpose of the Study:

  • To investigate the associations between 11 CVD subtypes and AD.
  • To explore the genetic overlap between AD and CVD traits.

Main Methods:

  • Logistic regression models were used in the UK Biobank (n=502,133) and All of Us Research Program (n=287,011).
  • Analyses were adjusted for demographic, lifestyle, and clinical factors.
  • Genome-wide association study (GWAS) data was used to colocalize significant single nucleotide polymorphisms (SNPs) for genetic overlap analysis.

Main Results:

  • Most CVD subtypes were significantly associated with AD in both cohorts.
  • Hypotension, hypertension, and cerebral infarction demonstrated the strongest associations with AD.
  • Genetic analyses identified shared loci between AD and CVD traits, including near *APOE* and *MAPT*.

Conclusions:

  • Subtype-specific CVD associations with AD were identified across diverse cohorts.
  • Shared genetic architecture underlies heart-brain interactions, emphasizing vascular health's importance in AD risk.
  • Hypotension may play an underrecognized role in cognitive decline.
Abstract

Keywords:
Alzheimer’s diseaseHeart–brain axiscardiovascular diseasecerebral infarctionhypotension

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