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Cannabidiol (CBD) and cognitive function in older adults: a mini review
Alicja Anna Binkowska1, Agnieszka Mateja1, Natalia Jakubowska2
1Institute of Psychology, Humanitas University, Sosnowiec, Poland.
Frontiers in Psychiatry
|September 15, 2025
Summary
Cannabidiol (CBD) shows potential for cognitive health in aging adults, but more research is needed. Studies on older adults are limited, and age may affect how well CBD works.
Area of Science:
- Neuroscience
- Pharmacology
- Gerontology
Background:
- The aging global population requires interventions to maintain cognitive health.
- Cannabidiol (CBD), a cannabis compound, has neuroprotective potential due to anti-inflammatory and antioxidant properties.
- Preclinical studies suggest CBD benefits cognitive function, but human data, especially in older adults, is scarce.
Purpose of the Study:
- To review current evidence on CBD's effects on cognitive function, focusing on age as a factor.
- To explore pharmacokinetic challenges and identify research gaps for CBD in older adults.
- To emphasize the need for rigorous clinical trials in aging populations.
Main Methods:
- Literature review synthesizing preclinical and clinical studies on CBD and cognition.
- Analysis of age-related changes in the endocannabinoid system and their impact on CBD efficacy.
- Identification of limitations in existing research, including study populations and administration routes.
Main Results:
- Existing human trials on CBD and cognition are limited, primarily in young adults with acute oral administration.
- Age-related changes in the endocannabinoid system may influence CBD's effectiveness in older individuals.
- Significant gaps exist in understanding CBD's long-term effects and optimal delivery in aging populations.
Conclusions:
- More research is needed to understand CBD's impact on cognitive function in older adults.
- Well-controlled trials using standardized cognitive assessments, neuroimaging, and biomarkers are essential.
- Evaluating CBD's therapeutic potential for cognitive health in an aging society requires age-specific investigation.
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