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Emergency Colectomy for Obstruction in Microsatellite Instability Colonic Cancer: A Complete Response Following

Lamribah Mohamed1, Lahoucine Alzaz2, Douah Dounya3

  • 1Surgery, Mohammed VI Hospital Agadir, Agadir, MAR.

Cureus
|September 15, 2025
PubMed
Summary

Neoadjuvant immunotherapy with pembrolizumab achieved a complete pathological response in a patient with microsatellite instability-high (MSI-H) colon cancer. This approach shows promise for managing MSI-H colorectal tumors, even in emergency surgical situations.

Keywords:
complete pathological responseemergency colectomyimmunotherapymsi-h colorectal cancerneoadjuvant therapy

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