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Published on: November 15, 2024
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Development of a Safe, Scalable, Course-Based Undergraduate Research Experience for Analytical Chemistry: The μCURE
Kimberley A Frederick1, Maury E Howard2, Kelly Y Neiles3
1Department of Chemistry, Skidmore College, Saratoga Springs, New York 12866, United States.
Journal of Chemical Education
|September 15, 2025
Summary
This study introduces a networked analytical chemistry course-based undergraduate research experience (CURE) where students adapt colorimetric assays for microfluidic paper analytical devices (μPADs), enhancing scientific skills.
Area of Science:
- Analytical Chemistry
- Chemical Education
- Biomedical Engineering
Background:
- Course-based undergraduate research experiences (CUREs) foster student learning and self-efficacy.
- Adapting established assays to new formats like microfluidic paper analytical devices (μPADs) presents unique pedagogical challenges.
- A networked, multi-institutional approach can broaden access to authentic research experiences.
Purpose of the Study:
- To design and implement a networked CURE for analytical chemistry courses.
- To focus the CURE on the process of adapting solution-phase colorimetric assays into μPAD assays.
- To develop and assess scaffolded learning outcomes related to scientific inquiry and collaboration.
Main Methods:
- Utilized backward design to establish five learning outcomes.
- Students conducted literature searches to identify assays for adaptation.
- Implemented a 3-5 week laboratory module with weekly data evaluation and experimental planning.
- Assessed student work using rubrics from the Enhancing Learning by Improving Process Skills in STEM (ELIPSS) Project.
Main Results:
- Student artifacts demonstrated partial to full attainment of learning outcomes.
- The project successfully guided students through adapting assays to μPADs.
- A networked CURE model facilitated collaborative learning across institutions.
Conclusions:
- The developed CURE effectively enhances students' scientific process skills.
- Adapting assays to μPADs provides a valuable, hands-on research experience.
- Networked CUREs are a viable model for delivering authentic research opportunities in STEM education.

