Exposing the Influence of Preceding Sexual Behavior in Younger Years toward Prostate Cancer Occurrence: Qualitative...

Area of Science:

• Urology
• Oncology
• Epidemiology

Background:

• Prostate cancer (PCa) is multifactorial, with sexual behaviors underexplored as a risk factor.
• The prostate's role in sexual function highlights the potential link between sexual activity and PCa.
• Understanding these links can inform prostate cancer prevention strategies.

Purpose of the Study:

• To qualitatively assess the relationship between ejaculation frequency (EF), first sexual activity (FSA), and lifetime sexual partner (SP) count and PCa occurrence.
• To explore how different sexual behaviors in early adulthood may modify PCa risk.
• To synthesize existing evidence on sexual behaviors and prostate cancer risk.

Main Methods:

• Systematic literature review following PRISMA guidelines.
• Inclusion of retrospective cohort and case-control studies published since 2000.
• Data extraction on EF, first sexual activity (FSA), and lifetime sexual partner (SP) count; quality assessment using Newcastle-Ottawa Scale.

Main Results:

• Higher ejaculation frequency from sexual intercourse (≥5-12/month) associated with reduced PCa risk.
• Frequent masturbation (≥2-7/week) potentially linked to increased PCa risk.
• Higher lifetime sexual partner count (7-21) generally associated with increased PCa risk, possibly due to STIs and inflammation.

Conclusions:

• Sexual behaviors in younger years may influence PCa development.
• Ejaculation frequency type, first sexual activity, and partner count are potential PCa risk modifiers.
• Further prospective studies are needed to refine sexual health and PCa prevention recommendations.