Study on Polyurethane Dipping Double-Layer Membrane Coating Method for Developing Polymer-Covered Stents.

Area of Science:

• Biomaterials Engineering
• Medical Device Technology
• Polymer Science

Background:

• Covered stents, often coated with silicone or e-PTFE, face challenges like drug delivery limitations and poor vascular application.
• Electrospinning offers multifunctionality for stent coatings, but issues like membrane delamination due to fiber weakness persist.

Purpose of the Study:

• To develop a novel double-layer membrane for covered stents by combining dipping and electrospinning methods.
• To enhance the mechanical properties and adhesion of stent coatings using polyurethane (PU).

Main Methods:

• Fabrication of a double-layer membrane using a combination of dipping and electrospinning techniques.
• Utilizing polyurethane (PU) as the primary material for the membrane.
• Evaluation of the mechanical properties and adhesion of the developed membrane to the stent.

Main Results:

• The developed double-layer PU membrane demonstrated high mechanical properties.
• Excellent adhesion of the membrane to the stent was confirmed.
• Significant improvement in the overall mechanical properties of the covered stent was observed.

Conclusions:

• The combined dipping and electrospinning method effectively creates a robust double-layer membrane for covered stents.
• This approach enhances adhesion and mechanical integrity, addressing limitations of existing electrospun stent coatings.
• The novel fabrication technique shows promise for improving the performance and applicability of covered stents.