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The China Brain Multi-omics Atlas Project (CBMAP).

Dan Zhou1,2,3, Yuan Zhou4, Zeyu Sun5,6

  • 1The Second Affiliated Hospital, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China. danzhou@zju.edu.cn.

Molecular Psychiatry
|September 15, 2025
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Summary
This summary is machine-generated.

The China Brain Multi-omics Atlas Project (CBMAP) creates a molecular map of 1000+ human brains, focusing on East Asian populations. This resource aids research into brain aging and disorders.

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Area of Science:

  • Neuroscience
  • Genomics
  • Proteomics
  • Metabolomics
  • Epigenomics

Background:

  • Underrepresentation of East Asian populations in global brain research.
  • Need for comprehensive molecular data in human brain studies.
  • Limited understanding of molecular basis for aging-related brain phenotypes and neuropsychiatric disorders.

Purpose of the Study:

  • To establish the China Brain Multi-omics Atlas Project (CBMAP) for a molecular reference map of human brains.
  • To address the underrepresentation of East Asian populations in brain research.
  • To provide a resource for studying aging-related brain phenotypes and neuropsychiatric disorders.

Main Methods:

  • Integration of multi-omics data: genome, epigenome, transcriptome, proteome, and metabolome.
  • Utilizing high-throughput omics technologies.
  • Employing advanced techniques including spatial transcriptomics, proteomics, and single-nucleus 3D chromatin structure analysis.

Main Results:

  • Generation of a comprehensive molecular reference map of over 1000 human brains (Phase I).
  • Inclusion of diverse age ranges and multiple regions across China.
  • Integration of diverse omics data types for a holistic view of brain molecular architecture.

Conclusions:

  • CBMAP provides an invaluable resource for brain science research.
  • The atlas will illuminate molecular underpinnings of brain aging and neuropsychiatric disorders.
  • CBMAP will enhance genome-wide association studies (GWAS) utility, accelerate drug discovery, and advance precision medicine for brain disorders.