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Advanced Multifunctional Bioactive Glass Nanoparticles: from Tissue Repair to Theranostics
Yanzi Zhao1, Weipeng Qiang1, Bo Lei1,2,3,4
1Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University,Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, P. R. China.
Advanced Healthcare Materials
|September 16, 2025
Summary
Multifunctional bioactive glass nanoparticles (BGNs) show promise in various biomedical applications, including tissue repair and theranostics. This review covers their structure, preparation, functionalization, and diverse clinical uses.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Multifunctional bioactive glass nanoparticles (BGNs) are gaining attention for their biocompatibility and versatility.
- Their nanoscale properties enable diverse biomedical functions, from tissue regeneration to targeted therapies.
Purpose of the Study:
- To review recent advancements in multifunctional BGNs.
- To summarize their physicochemical properties, preparation, and functionalization strategies.
- To explore their broad biomedical applications, including theranostics.
Main Methods:
- Comprehensive literature review of multifunctional BGNs.
- Analysis of BGNs' structural design and functionalization.
- Summary of applications in tissue repair, bioimaging, drug/gene delivery, and tumor therapy.
Main Results:
- Detailed overview of BGNs' structure-property relationships.
- Compilation of various preparation and functionalization techniques.
- Demonstration of BGNs' efficacy in diverse biomedical applications, including integrated therapeutic-repair platforms.
Conclusions:
- Multifunctional BGNs offer significant potential for advanced biomedical applications.
- Further research into structural optimization and functionalization will enhance clinical translation.
- BGNs are promising candidates for theranostics and regenerative medicine.

