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Updated: Apr 30, 2026

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Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice
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Reversal of ischemic cortical blindness with tenecteplase
Rui Tang1, Maryam Naser2, Saif Aldeen Alryalat2,3
1University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
American Journal of Ophthalmology Case Reports
|September 16, 2025
Summary
Tenecteplase (TNK) administration for acute ischemic stroke can cause reversible vision loss. This case highlights the importance of ophthalmological exams before and after TNK treatment.
Area of Science:
- Neuroscience
- Ophthalmology
- Cardiology
Background:
- Tenecteplase (TNK) is a modified alteplase with improved fibrin binding and longer half-life.
- Acute ischemic stroke requires prompt treatment to restore blood flow and minimize brain damage.
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