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Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
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Subclinical myocardial dysfunction in essential thrombocythemia: role of global longitudinal strain

Aykut Demirkıran1, Cihan Aydın1, Hüseyin Orta1

  • 1Department of Cardiology, Faculty of Medicine, Tekirdağ Namık Kemal University, Tekirdağ, Turkey.

Expert Review of Hematology
|September 16, 2025
PubMed

Insights

Essential thrombocytosis (ET) may reduce cardiac global longitudinal strain (GLS). The JAK2 mutation is associated with reduced GLS in ET patients, indicating potential cardiac implications.

Area of Science:

  • Cardiology
  • Hematology
  • Oncology

Background:

  • Essential thrombocytosis (ET) is a myeloproliferative neoplasm.
  • Cardiac involvement in ET is not fully understood.
  • Global longitudinal strain (GLS) is a sensitive measure of cardiac function.

Purpose of the Study:

  • To evaluate cardiac global longitudinal strain (GLS) in patients with essential thrombocytosis (ET).
  • To compare GLS between ET patients and healthy controls.
  • To investigate the association between GLS and the JAK2 mutation in ET.

Main Methods:

  • Transthoracic echocardiography was performed on 60 ET patients and 32 healthy controls.
  • GLS and routine echocardiographic parameters were compared between groups.
  • Logistic regression analysis was used to assess associations with GLS.

Main Results:

  • ET patients exhibited significantly reduced GLS compared to controls (16.5 ± 2.4% vs. 22.5 ± 2.2%, p=0.024).
  • Reduced GLS (≤18%) was more prevalent in ET patients with the JAK2 mutation (81.1% vs. 21.7%, p<0.001).
  • The JAK2 mutation was independently associated with reduced GLS (OR: 4.6, p=0.04).

Conclusions:

  • Essential thrombocytosis may lead to reduced cardiac global longitudinal strain.
  • The presence of the JAK2 mutation is linked to diminished GLS in ET patients.
  • These findings suggest potential subclinical cardiac dysfunction in ET, particularly with JAK2 mutation.
Abstract

Keywords:
Essential thrombocytosisJAK2 mutationglobal longitudinal strainleft ventricular ejection fractionspeckle-tracking echocardiography

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