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Updated: Jan 17, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

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Exploring the Causal Association Between Oral Microbiome Abundance and Asthma Risk Using Two-Sample Mendelian

Huagui Han¹, Lingwen Zhang², Yawei Wu²

¹Department of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China.

Pediatric Pulmonology

|September 16, 2025

Summary

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This summary is machine-generated.

This study explored the link between oral bacteria and asthma risk. Increased abundance of the oral bacterium Rothia was associated with higher asthma risk, suggesting a causal connection.

Area of Science:

Microbiome Research
Genetics
Respiratory Health

Background:

Asthma pathogenesis is influenced by genetic and environmental factors.
Emerging evidence suggests the oral microbiome may play a role in asthma development.
This study investigates the causal association between oral microbiome and asthma risk.

Purpose of the Study:

To explore the causal association between oral microbiome abundance and asthma risk.
To utilize a two-sample Mendelian randomization (MR) approach for robust analysis.
To identify specific oral bacteria linked to asthma susceptibility.

Main Methods:

Employed a two-sample Mendelian randomization (MR) approach.
Utilized genome-wide association studies (GWAS) data from 56,167 asthma cases and 408,442 controls.

Keywords:

GWAS Mendelian randomization asthma causal association genus rothia oral microbiome streptococcus

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Selected 267 single nucleotide polymorphisms (SNPs) associated with salivary microbiota as instrumental variables (IVs).

Main Results:

Identified a significant positive association between increased abundance of Genus Rothia and asthma risk (OR=1.03).
Observed a negative correlation between an unspecified Streptococcus species and asthma risk (OR=0.97).
Sensitivity analyses confirmed the robustness of findings, showing no significant pleiotropy or heterogeneity.

Conclusions:

Suggests a potential causal relationship between specific oral microbiota and asthma risk.
Highlights the oral microbiome as a significant factor in asthma pathogenesis.
Provides a foundation for further research into oral microbiome-targeted asthma interventions.