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Clinical features in severe opisthorchiasis viverrini
The Southeast Asian Journal of Tropical Medicine and Public Health
|September 1, 1985
Summary
Severe opisthorchiasis presents with obstructive jaundice and biliary issues, often without high fecal egg counts. Diagnosis may require direct visualization of Opisthorchis viverrini in bile ducts.
Area of Science:
- Hepatology
- Infectious Diseases
- Gastroenterology
Background:
- Opisthorchiasis, caused by Opisthorchis viverrini, is a significant public health concern in Southeast Asia.
- Severe cases can lead to serious complications affecting the biliary system and liver.
Purpose of the Study:
- To describe the clinical features of severe opisthorchiasis.
- To investigate the correlation between clinical presentation and diagnostic markers.
Main Methods:
- Retrospective analysis of 88 patients with severe opisthorchiasis.
- Clinical data collection including symptoms, physical examination, and laboratory results.
- Correlation analysis between fecal egg output and disease severity.
Main Results:
- Obstructive jaundice was a common presentation (affecting 25% with secondary infection), along with cholangitis, cholecystitis, and hepatomegaly.
- Biochemical abnormalities included elevated alkaline phosphatase (80%), transaminases (78%), and bilirubin (46%), with low albumin (62%).
- No correlation was found between fecal egg output and disease severity; some patients with obstructive jaundice had low or no eggs in stool.
Conclusions:
- Clinical manifestations of severe opisthorchiasis are diverse and can include significant biliary pathology.
- Fecal egg counts may not accurately reflect disease severity, especially in obstructive jaundice.
- Direct detection of Opisthorchis viverrini in the biliary system is crucial for diagnosis in some cases.