Decoding the multifactorial etiology of chronic endometritis.
Guanying You1, Shuyi Yu1, Meng Liu1
1Shenzhen Key Laboratory of Reproductive Immunology for Peri-implantation, Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen Zhongshan Obstetrics & Gynecology Hospital (formerly Shenzhen Zhongshan Urology Hospital), China; Guangdong Engineering Technology Research Center of Reproductive Immunology for Peri-implantation), China.
Placenta
|September 16, 2025
Summary
Chronic endometritis (CE), an endometrial inflammation linked to poor pregnancy outcomes, stems from diverse infectious and non-infectious causes. Personalized management integrating microbial and immune factors may improve outcomes for affected women.
Area of Science:
- Reproductive Medicine
- Gynecology
- Immunology
Background:
- Chronic endometritis (CE) is a persistent endometrial inflammation characterized by plasma cell infiltration.
- CE is significantly associated with adverse pregnancy outcomes, impacting fertility and gestation.
- Understanding CE pathogenesis is crucial for improving reproductive health.
Purpose of the Study:
- To elucidate the multifactorial etiology of chronic endometritis.
- To explore the interplay between infectious and non-infectious factors in CE development.
- To highlight the potential of personalized management strategies for CE.
Main Methods:
- Review of current literature on CE pathogenesis.
- Analysis of infectious pathways (ascending, pelvic, sexual, hematogenous, special infections).
- Identification of non-infectious contributing factors (uterine pathology, autoimmune disorders, iatrogenic causes).
Main Results:
- CE pathogenesis is complex, involving both microbial and immune system dysregulation.
- Infectious causes include various transmission routes and specific pathogens.
- Non-infectious factors such as uterine structural issues and autoimmune conditions also contribute significantly.
Conclusions:
- Chronic endometritis has a multifactorial etiology.
- Personalized management integrating microbial and immune assessments is proposed.
- This approach may enhance pregnancy outcomes for women with CE.
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