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EcoFoldDB: Protein Structure-Guided Functional Profiling of Ecologically Relevant Microbial Traits at the Metagenome

Timothy M Ghaly1,2, Vaheesan Rajabal1,2, Dylan Russell1,2

  • 1School of Natural Sciences, Macquarie University, Sydney, Australia.

Environmental Microbiology
|September 17, 2025
PubMed
Summary

EcoFoldDB uses protein structure to improve microbial gene function annotation in metagenomics. This new method enhances the discovery of microbial traits and ecological insights from environmental DNA.

Keywords:
biogeochemical cyclingmetagenomic annotationsplant growth‐promotionprotein foldingprotein functionprotein homology detectionstructural bioinformatics

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