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Published on: February 28, 2018
Changes in intestinal microbiota in patients with pancreatic cancer: a systematic review and meta-analysis
Meng Liang1, Zheng Liu2, Rui Zhang1
1Department of Hepatobiliary Surgery, Affiliated Hospital of Hebei University, Baoding, China.
Background:
Pancreatic cancer (PC) is a highly aggressive malignancy with an asymptomatic early stage, often resulting in rapid invasion of adjacent tissues and organs and a high mortality rate. Recent research has increasingly examined the gut microbiome as a potential factor in PC pathogenesis. Although changes in gut microbiota composition have been reported in patients with PC, a comprehensive evaluation of the relationship between gut microbiota and PC has not been systematically conducted.
Methods:
A systematic search of PubMed, Web of Science, Embase, and Cochrane databases was conducted, and a meta-analysis was performed on 10 studies including a total of 324 patients with PC.
Results:
The meta-analysis did not identify a statistically significant difference in α-diversity and microbial richness between patients with PC and those in the control group. However, a decrease in Bacteroides, Neisseria, Porphyromonas, Prevotella, and Actinomyces was observed in patients with PC, while Fusobacterium, Rothia, Streptococcus, Veillonella, and Escherichia-Shigella levels were increased.
Conclusion:
This meta-analysis demonstrates an association between PC and changes in gut microbiota composition at both the species and genus levels.
Systematic Review Registration:
https://www.crd.york.ac.uk/PROSPERO/recorddashboard, identifier CRD42023468159.
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