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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Related Experiment Video

Updated: Jan 17, 2026

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
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Re-thinking Walkability: Synergizing the Pedestrian Environment and Land Use Patterns to Promote Physical Activity in

Binay Adhikari1,2, Abby C King3, James F Sallis4

  • 1Schools of Community and Regional Planning, and Population and Public Health, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

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Summary
This summary is machine-generated.

Combining neighborhood walkability and streetscape design benefits older adults

Keywords:
GISUrban designaccelerometeraging in placebuilt environmenthealthy citieswalking

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Area of Science:

  • Urban planning and public health
  • Gerontology and environmental psychology

Background:

  • Macro-level urban design (e.g., walkability) and micro-level streetscape design influence physical activity.
  • Synergies between these design levels for health benefits, particularly in older adults, are understudied.

Purpose of the Study:

  • To examine interactions between neighborhood walkability, pedestrian environment, sex, and income on physical activity in older adults.
  • To identify how combined urban design features optimize health impacts for seniors.

Main Methods:

  • Cross-sectional study of 352 older adults in Seattle/King County.
  • Assessed self-reported active transportation and device-measured physical activity.
  • Analyzed interactions between macro- and micro-level environmental factors and demographics.

Main Results:

  • Positive interactions found between neighborhood walkability, pedestrian environment, and sex for active transportation.
  • Synergistic effects were more pronounced in older women, particularly concerning streetscape features and crossing safety.
  • Older women showed enhanced benefits from combined walkability and pedestrian environment features.

Conclusions:

  • Actionable policies can create age-friendly pedestrian environments by enhancing route connectivity, streetscape features, and crossing safety.
  • Prioritizing well-designed pedestrian infrastructure supports active travel and reduces motorized transport reliance in older adults.
  • The pedestrian environment can amplify the health benefits of neighborhood walkability for specific groups, like older women.