Related Experiment Video
Updated: Jan 17, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
Exploring the frontier of non-coding RNAs: biogenesis, functional diversity, and disease associations of circRNAs and
Hilal-Nur Calisir1, Sila Akcay1, Enes Bal1
1Department of Molecular Biology and Genetics, Istanbul Kultur University, Bakırkoy Campus, Ataköy Building, E5 Highway, Bakırköy, Istanbul, 34158, Turkey.
Abstract:
Non-coding RNAs (ncRNAs) represent a pivotal frontier in molecular biology, expanding our understanding of genetic regulation beyond the classical central dogma. Among these, circular RNAs (circRNAs) and tiny RNAs (tyRNAs) have emerged as critical regulators with diverse roles in gene expression, cellular homeostasis, and disease pathogenesis. CircRNAs, characterized by their covalently closed structures, exhibit remarkable stability and functional versatility, including acting as microRNA sponges, transcriptional regulators, and protein scaffolds. Tiny RNAs, a newly recognized class of ncRNAs, are implicated in post-transcriptional regulation through interactions with Argonaute proteins, influencing pathways from viral defense to neurodegenerative diseases. This review synthesizes recent advancements in the biogenesis, molecular mechanisms, and clinical significance of circRNAs and tyRNAs, highlighting their potential as biomarkers and therapeutic targets in cancer, metabolic disorders, and neurological conditions. By exploring their unique regulatory landscapes, this work aims to inspire further research into the ncRNA universe and its implications for human health.
Related Concept Videos
siRNA - Small Interfering RNAs
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
lncRNA - Long Non-coding RNAs
lncRNA - Long Non-coding RNAs
piRNA - Piwi-interacting RNAs
Types of RNA
RNA Performs Diverse...
Types of RNA
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...

