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Related Concept Videos

Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

430
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
430
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

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Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
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Pre-Trauma THC Use Is Associated With a Positive Posttraumatic Adjustment Scale Screening.

Jeremy Miller1, Claudia Alvarez1, Lauren Berki1

  • 1Division of Trauma and Acute Care Surgery, Department of Surgery, Desert Regional Medical Center, Palm Springs, CA, USA.

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|September 17, 2025
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Summary
This summary is machine-generated.

Pre-trauma tetrahydrocannabinol (THC) use is linked to higher posttraumatic stress disorder (PTSD) symptom screening in trauma patients. This suggests cannabis use may indicate increased vulnerability to psychological distress after injury.

Keywords:
traumatrauma acute care

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Area of Science:

  • Trauma Care
  • Psychiatry
  • Cannabinoid Research

Background:

  • Increasing cannabis use, particularly tetrahydrocannabinol (THC), is noted, with some perceiving it as therapeutic for psychiatric conditions.
  • The association between pre-injury THC use and the subsequent development of posttraumatic stress disorder (PTSD) symptoms remains unclear.
  • Understanding this relationship is crucial for trauma patient care and mental health interventions.

Purpose of the Study:

  • To determine the association between tetrahydrocannabinol (THC) use and positive screening for posttraumatic stress symptoms.
  • To evaluate THC use in relation to the Posttraumatic Adjustment Scale (PAS) in adult trauma patients.
  • To identify predictors of positive PAS screening in a trauma population.

Main Methods:

  • Retrospective cohort study at a Level 1 trauma center (January 2023 - December 2024).
  • Inclusion of adult trauma patients who completed inpatient PAS screening.
  • Analysis using multivariable logistic regression, adjusting for covariates, with THC use identified via urine drug screen.

Main Results:

  • Among 1960 patients, 22.3% screened positive for PTSD symptoms (PAS-positive).
  • Tetrahydrocannabinol (THC) use was significantly more common in PAS-positive patients (19.6% vs 13.2%, P = 0.001).
  • THC use remained an independent predictor of positive PAS screening (OR 1.66, P = 0.001), alongside polysubstance use and injury characteristics.

Conclusions:

  • Recent tetrahydrocannabinol (THC) use is independently associated with positive posttraumatic stress symptom screening in trauma patients.
  • Findings suggest baseline cannabis use may indicate heightened vulnerability to psychological distress following trauma.
  • Results emphasize the need for targeted screening and intervention for trauma patients with a history of THC use, questioning its self-medication role.