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Quantitative Susceptibility Mapping and Iron Deposition in Autopsy-Confirmed Progressive Supranuclear Palsy
Ryota Satoh1, Hiroaki Sekiya2, Farwa Ali3
1Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Movement Disorders Clinical Practice
|September 17, 2025
Summary
Quantitative susceptibility mapping (QSM) reveals distinct iron accumulation patterns in progressive supranuclear palsy (PSP). This neuroimaging technique shows potential for reliably evaluating iron in PSP patients.
Area of Science:
- Neuroimaging
- Biomarker Discovery
- Neurodegenerative Diseases
Background:
- Quantitative susceptibility mapping (QSM) is a potential biomarker for detecting abnormal iron deposition in progressive supranuclear palsy (PSP).
- The QSM profile and its diagnostic accuracy in autopsy-confirmed PSP have not been previously explored.
Purpose of the Study:
- To elucidate and validate the QSM profiles in autopsy-confirmed PSP.
- To investigate the utility of QSM as a biomarker for iron accumulation in PSP.
Main Methods:
- Eight patients with clinically diagnosed PSP underwent 3T MRI for QSM analysis.
- Pathological diagnosis confirmed 6 PSP and 2 multiple system atrophy (MSA) cases; QSM and Prussian blue staining were performed on subcortical regions.
Main Results:
- PSP cases exhibited higher susceptibility in the pallidum, subthalamic nucleus, substantia nigra, and cerebellar dentate compared to controls (FDR-corrected P < 0.05).
- PSP showed higher subthalamic nucleus and lower putamen susceptibility than atypical MSA (P = 0.08).
- Subcortical QSM values correlated significantly with Prussian blue staining (r = 0.63, P < 0.001).
Conclusions:
- QSM is a reliable method for assessing abnormal iron accumulation patterns in PSP.
- QSM may serve as a valuable neuroimaging biomarker for PSP diagnosis and monitoring.
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