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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
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Continuous infusion of Beta-Lactams in the critically ill: Considerations for global implementation
Kerina J Denny1, Janis Best-Lane2, Stephen J Brett2
1Intensive Care Unit, Gold Coast University Hospital, Queensland, Australia.
Journal of Critical Care
|September 17, 2025
Summary
Continuous infusion (CI) of β-lactam antibiotics optimizes treatment for critically ill patients. This strategy requires addressing practical barriers, especially in low-resource settings, to improve patient outcomes.
Area of Science:
- Pharmacology
- Critical Care Medicine
- Infectious Diseases
Background:
- β-lactam antibiotics are crucial for treating infections in critically ill patients.
- Optimizing β-lactam dosing is essential for reducing morbidity and mortality.
- Continuous infusion (CI) is an evidence-based strategy for β-lactam administration.
Purpose of the Study:
- To address barriers to the widespread implementation of CI β-lactam therapy.
- To provide practical solutions for translating CI evidence into clinical practice.
- To consider specific challenges in low-resource settings for CI implementation.
Main Methods:
- Literature review on CI β-lactam administration.
- Analysis of practical and pharmaceutical challenges.
- Identification of solutions for implementation in diverse healthcare settings.
Main Results:
- CI of β-lactams offers optimized dosing for critically ill patients.
- Practical and pharmaceutical factors pose significant barriers to CI adoption.
- Specific strategies are needed for successful CI implementation, particularly in resource-limited environments.
Conclusions:
- CI of β-lactam antibiotics is a valuable strategy for critically ill patients.
- Overcoming implementation barriers is key to realizing the benefits of CI.
- Tailored approaches are necessary to facilitate CI use in all healthcare settings.
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