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Updated: Jan 17, 2026
08:45
Determination of Mitochondrial Respiration and Glycolysis in Ex Vivo Retinal Tissue Samples
Published on: August 4, 2021
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Role of mitochondrial dysfunction in ocular surface diseases.
Xiaohan Chen1, Jiaxu Hong2,3,4,5, Qihua Le1,3
1Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
Cell Stress
|September 18, 2025
Summary
Mitochondrial dysfunction contributes to ocular surface diseases by impairing energy production and causing cellular damage. Investigating mitochondrial therapies offers potential new treatments for conditions like dry eye.
Area of Science:
- Cell Biology
- Ophthalmology
- Pathology
Background:
- Mitochondrial dysfunction, characterized by impaired energy production and cellular damage, is implicated in various diseases.
- Its presence is noted in ocular surface diseases including dry eye, Fuchs corneal endothelial dystrophy, and diabetic keratopathy.
- However, the precise role and molecular mechanisms of mitochondrial dysfunction in these eye conditions remain unclear.
Purpose of the Study:
- To review the pathological features and mechanisms of mitochondrial dysfunction in ocular surface disease pathogenesis.
- To discuss the potential of mitochondrial-based therapies for treating these eye conditions.
Main Methods:
- Literature review of studies on mitochondrial dysfunction and ocular surface diseases.
- Analysis of pathological alterations and molecular mechanisms.
- Evaluation of current and potential mitochondrial therapies.
Main Results:
- Mitochondrial dysfunction leads to energy deficits, reactive oxygen species accumulation, inflammation, and DNA damage in ocular cells.
- These pathological changes are linked to the development and worsening of ocular surface diseases.
- Current mitochondrial therapies for these conditions are still in the research phase.
Conclusions:
- Mitochondrial dysfunction is a significant factor in the pathogenesis of ocular surface diseases.
- Understanding these mechanisms is crucial for developing effective treatments.
- Mitochondrial therapies hold promise for future treatment strategies in ophthalmology.
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