Inventive pectic acid grafted with polyacrylamide for a highly sensitive and selective non-enzymatic dopamine sensor...

Area of Science:

• Materials Science
• Electrochemistry
• Analytical Chemistry

Background:

• Pectic acid is a natural polysaccharide with potential for material modification.
• Developing efficient electrochemical sensors for neurotransmitters like dopamine is crucial for diagnostics.

Purpose of the Study:

• To synthesize and characterize polyacrylamide grafted pectic acid (PAAm-g-PA).
• To develop a novel electrochemical sensor based on PAAm-g-PA modified screen-printed carbon electrodes (SPCE) for dopamine detection.
• To evaluate the sensor's performance, including sensitivity, selectivity, stability, and applicability in pharmaceutical samples.

Main Methods:

• Grafting polymerization was used to synthesize PAAm-g-PA.
• Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDX) were employed for material characterization.
• Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used for electrochemical analysis and dopamine detection.

Main Results:

• Optimized reaction conditions yielded high-quality PAAm-g-PA.
• The PAAm-g-PA/SPCE demonstrated enhanced electro-catalytic activity for dopamine oxidation.
• The sensor exhibited a wide linear range (0.01–220 μM) and a low detection limit (3.0 nM) for dopamine.
• The sensor showed good selectivity, stability, reproducibility, and satisfactory recovery rates in pharmaceutical samples.

Conclusions:

• The synthesized PAAm-g-PA is a promising material for electrochemical sensing applications.
• The PAAm-g-PA/SPCE offers a sensitive, selective, and stable platform for dopamine monitoring.
• The developed sensor has practical utility for analyzing dopamine in pharmaceutical formulations.