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Successful Management of Esophageal Sarcomatoid Carcinoma with Neoadjuvant Chemotherapy and Esophagectomy
Keiichiro Yokota1, Hiroyuki Kitagawa1, Kohei Araki1
1Department of Surgery, Kochi Medical School, Nankoku, Kochi, Japan.
Introduction:
Esophageal sarcomatoid carcinoma (ESC) is a rare malignancy characterized by both carcinomatous and sarcomatous components, with no established perioperative chemotherapy standards.
Case Presentation:
We report a case of advanced ESC (T3N1M0, Stage III) treated with 2 courses of neoadjuvant docetaxel, cisplatin, and fluorouracil (DCF) chemotherapy, followed by robotic-assisted thoracoscopic esophagectomy. Histopathology revealed the complete disappearance of spindle cell components, although residual squamous cell carcinoma was found in the flat mucosa. The patient remained recurrence-free for 26 months postoperatively without adjuvant therapy.
Conclusions:
This case suggests that preoperative DCF chemotherapy may be effective for ESC, especially when combined with complete surgical resection, highlighting the importance of addressing both the sarcomatoid and squamous components for long-term survival.
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