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[Multicenter study of asphyxia neonatorum].

M T Esqué, R Baraíbar, J Figueras

    Anales Espanoles De Pediatria
    |December 1, 1985
    PubMed
    Summary

    This study identified risk factors for hypoxic-ischemic encephalopathy (HIE) in newborns. Umbilical artery pH and fetal distress were sensitive indicators, while Apgar scores and resuscitation needs were highly specific for predicting HIE.

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    Area of Science:

    • Neonatal Medicine
    • Perinatal Neurology
    • Pediatric Critical Care

    Context:

    • Hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal mortality and morbidity.
    • Identifying at-risk newborns early is crucial for timely intervention and improved outcomes.
    • This study evaluated risk criteria in a large cohort of term infants.

    Purpose:

    • To assess the incidence and mortality of HIE in term infants.
    • To evaluate the predictive accuracy of various clinical and laboratory criteria for HIE.
    • To identify the most sensitive, specific, and efficient predictors of HIE.

    Summary:

    • A study of 14,673 term infants identified 215 at risk for HIE based on criteria including low pH, abnormal heart rates, low Apgar scores, or need for resuscitation.

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  • The incidence of HIE was 6.39% with a mortality rate of 0.55%.
  • Abnormal neurological examinations were noted in 43.7% of at-risk infants, with severe symptoms in 10%.

    • Impact:

    • Fetal distress and umbilical artery pH demonstrated high sensitivity for HIE risk.
    • Need for neonatal resuscitation and 5-minute Apgar scores ≤6 showed high specificity.
    • The study provides valuable insights into optimizing HIE risk assessment and management strategies.