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Comparative Analysis Revealed Circulating Methylation of PDGFRB Highly Related with Rheumatoid Arthritis Related
Yu Shan1,2,3, Mengru Guo1,2,3, Jia Liu1,2,3
1Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Endocrine, Metabolic & Immune Disorders Drug Targets
|September 18, 2025
Summary
DNA methylation levels of platelet-derived growth factor receptor-B (PDGFRB) cg25613180 are lower in rheumatoid arthritis (RA) patients compared to healthy controls. This finding suggests PDGFRB methylation may serve as a diagnostic biomarker for RA and other rheumatic diseases.
Area of Science:
- Epigenetics
- Molecular Biology
- Rheumatology
Background:
- Rheumatoid arthritis (RA) and other rheumatic diseases share complex etiologies.
- DNA methylation is a key epigenetic mechanism influencing gene expression.
- Platelet-derived growth factor receptor-B (PDGFRB) is implicated in cellular processes relevant to autoimmune diseases.
Purpose of the Study:
- To investigate DNA methylation levels of PDGFRB cg25613180 in RA and compare them with other rheumatic disorders.
- To explore the correlation between PDGFRB cg25613180 methylation and clinical indices in RA.
- To assess the potential of PDGFRB methylation as a diagnostic biomarker for RA.
Main Methods:
- Targeted DNA methylation sequencing was used to analyze PDGFRB cg25613180 methylation.
- A cohort included RA patients, healthy controls (HC), and patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA), gout, systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and dermatomyositis (DM).
- Pearson's correlation, univariate, and multivariate logistic regression analyses were performed.
Main Results:
- RA patients exhibited significantly lower PDGFRB cg25613180 methylation levels than HCs, with similar trends in SLE and DM.
- Methylation levels showed a negative correlation with C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in RA patients.
- Haplotype methylation analysis revealed significant differences between RA and other groups, particularly for CCCC and TCCC haplotypes, enhancing diagnostic accuracy.
Conclusions:
- PDGFRB methylation at cg25613180 displays distinct patterns in RA compared to other rheumatic diseases, indicating its potential as a diagnostic biomarker.
- The negative correlation with inflammatory markers suggests a role for PDGFRB methylation in RA pathogenesis.
- Haplotype-specific methylation analysis improves diagnostic accuracy for differentiating RA from other rheumatic conditions.
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