Related Experiment Video
Updated: Jan 17, 2026
07:13
Early Detection of Cyanobacterial Blooms and Associated Cyanotoxins using Fast Detection Strategy
Published on: February 25, 2021
4.4K
Natural Products Repository of Costa Rica (NAPRORE-CR): An Open-Access Database
Daniel A Acuña-Jiménez1, Jose Rodríguez-Zúñiga2, Daniela Gutiérrez-Ramírez2
1DIFACQUIM Research Group, Department of Pharmacy, School of Chemistry, Universidad Nacional Autónoma de México, Avenida Universidad 3000, Mexico City 04510, México.
Journal of Chemical Information and Modeling
|September 18, 2025
Summary
Costa Rica
Area of Science:
- Natural product chemistry
- Bioinformatics
- Drug discovery
Background:
- Natural products are vital sources of bioactive compounds for drug discovery, cosmetics, and pesticides.
- Costa Rica is a global biodiversity hotspot, making it a rich source for novel natural products.
- Existing databases lack comprehensive collections of natural products specifically from Costa Rica.
Purpose of the Study:
- To establish the Natural Products Repository of Costa Rica (NAPRORE-CR), a dedicated database for natural products from Costa Rica.
- To compile structural data and predicted properties of these compounds.
- To assess their potential applications in various industries.
Main Methods:
- Compilation of 1161 natural products from Costa Rica.
- Annotation with structural classifications and physicochemical properties (e.g., MW, HBD, HBA, RB, AlogP, TPSA).
- Calculation of complex descriptors (e.g., SA score, QED, nSPS) and comparison with drugs, pesticides, and cosmetics.
- Cross-referencing with PubChem and ChEMBL for activity prediction.
Main Results:
- NAPRORE-CR version 1 contains 1161 compounds with diverse structural and physicochemical properties.
- Compounds exhibit property profiles suitable for drug discovery, cosmetic, and natural pesticide applications.
- Structural similarity was observed between NAPRORE-CR compounds and existing drugs and natural pesticides.
- Potential new applications were identified through activity prediction.
Conclusions:
- NAPRORE-CR is the first database of its kind for Costa Rican natural products, supporting open science and FAIR data principles.
- The repository's compounds show significant potential for diverse industrial applications.
- NAPRORE-CR serves as a valuable resource for identifying novel bioactive compounds and guiding future research.
More Related Videos
Related Concept Videos
01:24Biodiversity and Human Values
16.4K
Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.
16.4K
01:19What is Biodiversity?
32.8K
Biodiversity describes the variety of living things at multiple organizational levels: genetic, species and ecosystem diversity. Species diversity includes all branches of the evolutionary tree from single-celled prokaryotic organisms, bacteria, and archaea, to the eukaryotic kingdoms: plants; animals; fungi; and protists. To date, there have been about 1.75 million species identified, and new species are discovered every week.
32.8K
00:53Products of the Citric Acid Cycle
103.2K
The cells of most organisms—including plants and animals—obtain usable energy through aerobic respiration, the oxygen-requiring version of cellular respiration. Aerobic respiration consists of four major stages: glycolysis, pyruvate oxidation, the citric acid cycle, and oxidative phosphorylation. The third major stage, the citric acid cycle, is also known as the Krebs cycle or tricarboxylic acid (TCA) cycle.
103.2K
01:50Threats to Biodiversity
26.6K
There have been five major extinction events throughout geological history, resulting in the elimination of biodiversity, followed by a rebound of species that adapted to the new conditions. In the current geological epoch, the Holocene, there is a sixth extinction event in progress. This mass extinction has been attributed to human activities and is thus provisionally called the Anthropocene. In 2019 the human population reached 7.7 billion people and is projected to comprise 10 billion by...
26.6K
01:43Sustainable Development
14.8K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
14.8K
01:06Primary Production
25.1K
The total amount of energy acquired by primary producers in an ecosystem is called gross primary production (GPP). However, of this energy, producers use some for metabolic processes, and some is lost as heat, decreasing the amount of energy available to the next trophic level. The remaining usable amount of energy is called the net primary productivity (NPP). In terrestrial ecosystems, NPP is driven by climate, while light penetration and nutrient availability drive NPP in aquatic ecosystems.
25.1K