Characterization of Omics Components in Human Milk: A Systematic Review.

Area of Science:

• Human milk composition analysis
• Nutritional science
• Infant health

Background:

• Human milk's diverse
• Purpose_of_A_Systematic_Review_to_Characterize_the_Omics_Components_of_Human_Milk_According_to_Maternal_Health_and_Lactation_Phases_Summarizing_Current_Knowledge_Based_on_High-Resolution_Analytical_Techniques
• Main_Methods
• A_systematic_review_was_conducted_following_PRISMA_2020_guidelines_between_August_and_September_2022_using_multiple_databases_including_Medline_EMBASE_Scopus_LILACS_and_Web_of_Science.
• Observational_studies_analyzing_human_milk_using_mass_spectrometry_or_nuclear_magnetic_resonance_were_included_totaling_55_full-text_articles.
• Main_Results
• Glycomics_is_the_most_studied_area_in_human_milk_omics_followed_by_proteomics_metabolomics_and_lipidomics.
• Maternal_health_conditions_and_lactation_stages_significantly_impact_human_milk_composition.
• Specific_omics_patterns_are_linked_to_maternal_health_conditions_like_diabetes_hypothyroidism_obesity_and_allergies_and_infant_outcomes_such_as_sucking_ability_and_growth.
• Conclusions
• Understanding_human_milk_omics_profiles_can_inform_precise_nutrition_strategies_and_improve_infant_formula.
• Further_research_integrating_omics_data_with_maternal_and_infant_outcomes_is_crucial_for_advancing_infant_health_knowledge.
• Meta_Description': 'Human milk omics (proteome, lipidome, glycome, metabolome) vary with maternal health and lactation. Review highlights nutritional insights.'}

Purpose of the Study:

• Characterize human milk "omics" (proteome, lipidome, glycome, metabolome).
• Analyze variations based on maternal health and lactation phases.
• Summarize current knowledge using high-resolution analytical techniques.

Main Methods:

• Systematic review following PRISMA 2020 guidelines.
• Searched Medline, EMBASE, Scopus, LILACS, and Web of Science (Aug-Sep 2022).
• Included observational studies using mass spectrometry or NMR on human milk (55 articles).

Main Results:

• Glycomics is the most studied omics, followed by proteomics, metabolomics, and lipidomics.
• Maternal comorbidities and lactation stages influence human milk composition.
• Specific omics patterns identified in relation to maternal health (e.g., diabetes, obesity) and infant outcomes.

Conclusions:

• Understanding human milk omics guides precise nutrition and improves milk substitutes.
• Further research integrating omics with maternal/infant outcomes is essential.
• Advances knowledge to support infant health.