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Maternal inheritance suppresses CAA and amyloid plaques in 5xFAD (Tg7031)/APOE4 mice

Fareeha Saadi1, Ilia V Katritch1, Samira Parhizkar1

  • 1Department of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA; Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, 4488 Forest Park Avenue, St. Louis, MO 63108, USA.

Neuron
|September 18, 2025
PubMed
Abstract

No abstract available in PubMed .

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Lethal Alleles02:41

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Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...