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Influence of Preexisting Psychotic and Bipolar Disorders on the Outcomes of Acutely Hospitalized Patients With

Mojtaba Sharafkhah1, Nozhan Alimi2, Zeinab Haghighi Fini2

  • 1Graduate Program in Neuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON.

The Journal of Neuropsychiatry and Clinical Neurosciences
|September 19, 2025
PubMed

Insights

Patients with psychotic and bipolar disorders (PsBPs) experienced worse COVID-19 outcomes, including higher intensive care unit admission and mortality rates. Early detection and interventions are crucial for this vulnerable group.

Area of Science:

  • Psychiatry
  • Infectious Diseases
  • Public Health

Background:

  • Preexisting conditions significantly impact COVID-19 outcomes.
  • Psychotic and bipolar disorders (PsBPs) represent a vulnerable patient population.
  • Understanding the specific impact of PsBPs on COVID-19 is critical for targeted care.

Purpose of the Study:

  • To assess the impact of preexisting psychotic and bipolar disorders (PsBPs) on COVID-19 outcomes.
  • To compare COVID-19 severity and mortality rates between patients with and without PsBPs.

Main Methods:

  • Retrospective cohort study of 7,370 hospitalized COVID-19 patients.
  • Patients categorized into PsBP group and no psychiatric disorders (NPD) group.
  • Analysis of demographic data, clinical features, ICU admission, and in-hospital mortality.

Main Results:

  • 12.2% of COVID-19 patients had PsBPs.
  • PsBP group showed significantly higher ICU admission (44.5% vs. 21.8%) and mortality rates (39.2% vs. 23.8%).
  • Shorter time intervals to ICU admission and death were observed in the PsBP group.

Conclusions:

  • COVID-19 patients with PsBPs exhibit poorer outcomes, including increased severity, ICU admission, and mortality.
  • Findings underscore the need for early identification and specialized interventions for individuals with PsBPs.
  • Proactive management strategies are essential to mitigate adverse COVID-19 outcomes in this population.
Abstract

Keywords:
COVID-19Mental HealthMortality RatePsychiatric DisordersPsychosisSars-CoV-2

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