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Updated: Jan 17, 2026
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Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
Published on: May 22, 2013
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Telomere Length in Young Patients: Relationship With Metabolic Syndrome and Its Components
Anna Bragina1,2, Aida Tarzimanova1, Natalia Druzhinina1,2
1Department of Internal Medicine No. 2, Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 19991 Moscow, Russia.
Journal of Clinical Medicine Research
|September 19, 2025
Summary
Young patients with metabolic syndrome (MS) have shorter leukocyte telomere length. This study found associations between shorter telomeres and MS components like dyslipidemia, suggesting a link to premature aging.
Area of Science:
- Biomedical Science
- Genetics
- Cardiovascular Research
Background:
- Inconsistent findings exist regarding telomere length and metabolic syndrome (MS).
- Leukocyte telomere length (LTL) is a biomarker of cellular aging.
- MS is a cluster of conditions increasing cardiovascular disease risk.
Purpose of the Study:
- To investigate LTL in young adults without cardiovascular disease.
- To determine the relationship between LTL and MS and its individual components.
Main Methods:
- Study included 450 Caucasian patients (median age 30 years).
- Metabolic parameters assessed using CardioChek PA; integral metabolic indices calculated.
- LTL analyzed in a randomly selected subgroup of 45 participants.
Main Results:
- Median LTL was significantly lower in patients with MS (7.36 pn) compared to controls (8.72 pn).
- Age, smoking, neck circumference, triglycerides, HDL, LAP index, and dyslipidemia were significantly associated with LTL.
- Correlation and regression analyses revealed these associations.
Conclusions:
- Shorter LTL is observed in individuals with MS.
- Dyslipidemia is associated with premature telomere shortening.
- Further research is needed to establish a causal relationship.
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