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Reductive Preparation of Fluoroalkyl Copper Complexes from Perfluorinated Alkyl Iodides Using Diboron
Hayato Nishiguchi1, Sensuke Ogoshi1, Ryohei Doi2
1Department of Applied Chemistry, Faculty of Engineering, The University of Osaka, Suita, Osaka 565-0871, Japan.
None:
The reductive synthesis of fluoroalkyl copper phenanthroline complexes from fluoroalkyl iodides, using diboron as a reductant, is reported in this study. The structure of Cu(C4F9)(phen), isolated as a phosphine adduct, was confirmed by X-ray crystallography. These copper complexes underwent smooth cross-coupling with aryl iodides under mild conditions to afford fluoroalkylated arenes. Furthermore, a one-pot protocol enabled the reductive coupling of aryl iodides and fluoroalkyl iodides without the need to isolate the intermediate fluoroalkyl copper complexes.
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