eccDNABase: A Comprehensive and High-Quality Database for Extrachromosomal Circular DNA

Area of Science:

• Genomics
• Molecular Biology
• Bioinformatics

Background:

• Extrachromosomal circular DNA (eccDNA) are small, circular DNA molecules found in eukaryotes.
• eccDNAs are prevalent in human tissues and body fluids, implicated in tumorigenesis and poor clinical outcomes.

Purpose of the Study:

• To develop a comprehensive, curated database for eccDNA research.
• To systematically catalog eccDNA-disease associations across multiple species and tissues.

Main Methods:

• Developed eccDNABase, a database integrating eccDNA data.
• Cataloged eccDNA entries, species, diseases, and associated information.
• Included details on chromosomal localization, gene overlap, and detection methods.

Main Results:

• eccDNABase contains 1,875,452 eccDNA-disease associations.
• The database includes 8,398 eccDNA entries across nine species and 63 diseases.
• Detailed information on eccDNA characteristics and disease links is provided.

Conclusions:

• eccDNABase is a valuable resource for eccDNA research.
• Facilitates deeper insights into the role of eccDNA in health and disease.
• Provides a platform for basic and translational research.